pentobarbital will decrease the level or influence of ramelteon by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Not known.pentobarbital will reduce the extent or impact of brexpiprazole by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Intently. Double brexpiprazole dose in excess of 1-2 mo